Osteoradionecrosis of the jaws is a well known complication of head and neck radiotherapy. Extraction of teeth in radiated patients represents the most common cause for the development of osteoradionecrosis. The authors report two cases of extraction of multiple teeth in previously irradiated nasopharyngeal cancer patients. These extractions were performed with the use of pentoxifylline and tocopherol as a prophylaxis to prevent the occurrence of osteoradionecrosis. This is the first reported case of the use of these drugs to prevent osteoradionecrosis.