Chronological monitoring of coagulation factor VIII activity in patients with congenital hemophilia A who underwent teeth extraction treated with Turoctocog alfa:: report of 2 cases

Abstract

Hemophilia A is a hereditary disorder caused by missing factor VIII. When planning tooth extraction in patients with hemophilia A, attention should be paid to the risk of postoperative bleeding. We report two cases of patients with mild hemophilia A who underwent teeth extraction treated with Turoctocog alfa with close monitoring of coagulation factor VIII activity for 2 weeks. Notwithstanding the adequate replacement therapy with coagulation factor VIII and auxiliary hemostasis, postoperative bleeding was still observed more than once. Adequate explanation of the possibility of postoperative bleeding prior to the treatment to the patients is crucial in such cases. The development of new guidelines for teeth extraction of hemophilia A should be considered.